Fractures can lead to pain,limited mobility,and a decreased quality of life.Treatment typically involves surgical or conservative approaches,often accompanied by complications.Stem cell-derived exosomes(EXOs),characterized by excellent biocompatibility,low immunogenicity,intrinsic stability,and targeting ability,have emerged as a current research hotspot.Exosomes hold certain advantages in promoting fracture healing;they can regulate the functions of osteo-blasts and osteoclasts,angiogenesis,and cartilage regeneration,which may improve clinical treatment outcomes and reduce the incidence of fracture complications.In this article,we review the research progress on exosomes derived from human umbilical cord mesenchymal stem cells(HUC-MSCs)in promoting fracture healing,exploring the critical role of HUC-MSC-derived ex-osomes in this process.
关键词
人脐带间充质干细胞/外泌体/骨折愈合/成骨细胞/破骨细胞
Key words
human umbilical cord mesenchymal stem cells/exosomes/fracture healing/osteo-blasts/osteoclasts
维普
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