Research progress of ceRNA in animal hypoxic adaptation
Oxygen is an essential factor for the body's metabolism and survival.Hypoxic adaptation refers to a series of local and systemic changes that occur in the body to adapt to the physiological or pathological phenomenon of hypoxia,reducing the impact of hypoxia.Competing endogenous RNA(ceRNA)refers to RNA molecules that share the same microRNA response elements(MREs)and competitively bind to microRNAs to regulate gene expression at the post-transcriptional level,thereby influencing the biological functions of cells.ceRNA is a complex network regulation mechanism that plays a role in cell proliferation and apoptosis,inflammatory responses,energy metabolism,muscle development,fat deposition,lipid metabolism,and other aspects.The article summarizes the biological functions and characteristics of long noncoding RNA(lncRNA),circular RNA(circRNA),and pseudogenes.It elucidates the validated roles of ceRNA in the biological functions associated with animal hypoxic adaptation,providing reference for the study of mammalian hypoxia adaptability.
long noncoding RNAcircular RNApseudogenecompeting endogenous RNAhypoxic adaptation
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维普
