In order to evaluate the feeding safety of Astragalus flower,acute oral toxicity tests,Ames mutagenicity tests,mammalian erythrocyte micronucleus tests,mouse spermatogonial chromosomal aberration tests,and a 90-day subacute toxicity test were conducted on Astragalus flower in accordance with national food safety standards.The results showed that there were no obvious signs of toxicity or mortality in rats and mice 14 days after gastric administration of Astragalus flower.The maximum tolerated doses(LD50)for the acute oral toxicity test in rats and mice were greater than 20.00 g/kg BW.Three genetic toxicity tests were carried out using Astragalus flower extract,and the results indicated that the Astragalus flower extract did not induce reverse mutations in the tested bacterial strains.It had no significant impact on the micronucleus cell rate in mouse erythrocytes and showed no significant effects on the rate of chromosomal abnormal cells,autosomal univalent,and sex chromosome univalent.The 90-day oral toxicity test revealed that there were no significant changes in the weight gain,total food intake,and food utilization in the rats fed with different doses of Astragalus flower.Blood indicators and organ weights in rats showed no apparent toxicological changes.Anatomical and histological observations also did not reveal any significant pathological changes,and the no-observable-adverse-effect level was determined to be 1.20 g/kg BW.The study suggests that Astragalus flower has a high safety profile,exhibiting no mutagenicity and subacute toxicity at the tested doses.
Astragalus flowersafety evaluationgenetic toxicity testsacute toxicity testsubchronic toxicity test
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维普
