Anti-inflammatory effect of Abelmoschus manihot L.flower polysaccharides on LPS-induced inflammatory mice
The study aimed to investigate the anti-inflammatory effects of Abelmoschus manihot L.flower polysaccharides on a mouse inflammation model.Fifty-four Kunming mice were divided into a blank control(CK)group(0.9％NaCl),a lipopolysaccharide(LPS)model group(0.01 mg/g LPS),a dexamethasone(Dex)group(0.01 mg/g DXMS),a L group(0.2 mg/g Abelmoschus manihot L.flower polysaccharides),a M group(0.4 mg/g Abelmoschus manihot L.flower polysaccharides),and a H group(0.6 mg/g Abelmoschus manihot L.flower polysaccharides).Each group had nine replicates and one mice per repliate.Continuous gavage was performed for three days,and except for the CK group,all other groups were intraperitoneally injected with 0.01 mg/g LPS.The mice were euthanized 12 h later.The results showed that compared to the Dex group,the liver index and spleen index of mice in the three groups of Abelmoschus manihot L.flower polysaccharides had significant differences(P＜0.05).Compared to the LPS group,the M group exhibited an increase in NO release(P＜0.05).The H group showed a higher lymphocyte vitality and macrophage phagocytosis rate than the LPS group(P＜0.05).The expression levels of IL-6 and TNF-α in the liver of mice in the M group and H group were lower than those in the LPS group(P＜0.05).The study indicates that an appropriate dose of Abelmoschus manihot L.flower polysaccharides has a certain anti-inflammatory effect on LPS-induced inflammatory mice and has the potential to enhance the body's immune response.
万方数据
维普
