The purpose of this experiment was to study the effects of compound probiotic fermented feed on the growth performance,nutrient apparent digestibility,fecal microbial flora,and serum indexes of mutton sheep.Sixty-four(29.25±0.35)kg healthy Du-Han hybrid fattening rams were randomly divided into four groups with four replicates in each group and four sheep in each replicate.The control group,test group 1,test group 2,and test group 3 were fed with 0,5%,10%,and 15%compound probiotic fermented feed,respectively.The trial period was 60 days.The results showed that compared with the control group,the average daily gain of the test group 1 increased significantly(P<0.05).The final weight and average daily gain of the test group 2 and test group 3 increased significantly(P<0.05),and the feed-to-weight ratio decreased significantly(P<0.05).The apparent digestibility of CP,EE,NDF,and ADF in the test group 2 and test group 3 increased significantly(P<0.05).The number of Lactobacillus and Bifidobacterium in the test group 1,test group 2,and test group 3 increased significantly(P<0.05),while the number of Escherichia coli decreased significantly(P<0.05).The number of Salmonella in the test group 2 and test group 3 decreased significantly(P<0.05).Compared with the control group,the contentrations of IgG,IgA,IL-2,TNF-α,TP,ALB,T-AOC,and SOD activities were significantly increased(P<0.05),while the activities of ALT,AST,BUN,and MDA were significantly decreased(P<0.05).The result shows that adding 10%and 15%compound probiotic fermented feed to mutton sheep diet can improve the growth performance,fecal microbial flora and serum indexes of mutton sheep,and increase the apparent digestibility of nutrients.