Evaluation of feeding safety of Trollius chinensis
The purpose of the experiment was to explore the feeding safety of Trollius chinensis.Acute toxicity test,genotoxicity test(bacterial reversion mutation test,mammalian erythrocyte micronucleus test,mouse spermatocyte chromosome aberration),and subchronic toxicity test were conducted on Trollius chinensis.The results showed that the median lethal dose(LD50)of Kunming mice was more than 10.0 g/kg·BW.The results of the genotoxicity test showed no mutagenic effect of Trollius chinensis on experimental animals.The results of the rat teratogenicity test showed that there were no toxic signs,no reproductive toxicity,and no teratogenicity in pregnant rats of each dose group.The subchronic toxicity test showed no toxicity and death in rats.There was no significant difference in body weight,weight gain,food intake,food utilization rate,and viscera-body ratio between rats in each dose group and negative control group(P＞0.05).The blood routine,blood biochemistry,urine routine,and other indexes of rats in each group were all in the normal range,and the color,size,morphology,and structure of the main organs such as heart,liver,pancreas,lung,kidney,brain,stomach,testis,and uterus were not obviously abnormal.The study indicates that Trollius chinensis has low toxicity and high feeding safety.
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