Preparation of compound oregano oil nanoemulsion and its therapeutic effect on endometritis of sows
The purpose of the experiment was to prepare compound oregano oil nanoemulsion and to explore the therapeutic effect of compound oregano oil nanoemulsion on endometritis of sow.In the experiment,oregano oil and chlorhexidine acetate were used as pharmaceutical raw materials,suitable surfactants,co-surfactants and oil phases were selected,the formulas of nanoemulsions prepared by pseudo-ternary phase diagram method were screened,the quality and stability of nanoemulsions prepared by the test were preliminarily investigated,and the clinical porcine endometritis was treated in groups.The results showed that the appearance of the compound oregano oil nanoemulsion prepared by mixing RH-40 and Tween-80 as surfactant mass ratio of 1:1 was clear and transparent,the particle size was round spherical droplets,and the distribution was uniform,with no agglomeration,no stratification,no turbidity,and no precipitation.The clinical treatment experiment of endometritis showed that the duration of abnormal secretion of uterus was obviously shortened in the compound oregano oil nanoemulsion group Ⅰ and compound oregano oil nanoemulsion group Ⅱ,the cure rate of endometritis was significantly higher than that in the compound oregano oil nanoemulsion group Ⅲ,control group Ⅰ,and control group Ⅱ(P＜0.05),and the rate of re-estrus and conception were higher than those in other treatment groups.Studies has shown that compound oregano oil nanoemulsion has good stability and has obvious therapeutic effect on clinical endometritis of sow.
国家科技期刊平台
NSTL
万方数据
维普
