Exploring material basis and mechanism of Guiqi Yimu decoction in preventing and treating qi and blood deficiency of cattle based on network pharmacology
The study aimed to obtain the material basis and mechanism of Guiqi Yimu decoction to prevent and treat the deficiency of both qi and blood in cattle.The experiment screened out the effective active ingredients and corresponding targets of Guiqi Yimu decoction through the traditional Chinese medicine systems pharmacology(TCMSP)database.The durg-disease intersection targets were obtained through network pharmacology analysis.The targets protein interaction network was established and core targets and main active ingredients were screened out based the degree values.The GO function and KEGG signal pathway enrichment analysis of core targets were carried out and the top 10 signal pathways were obtained.The Cytoscape 3.8.2 software was used to establish the main active ingredients-core targets-top 10 signal pathway network of Guiqi Yimu decoction.The Autodock 1.5.7 software was used to conduct molecular docking between active ingredients and core targets.The results showed that 11 main ingredients of Guiqi Yimu decotion and 16 core targets were screened out.Through GO functional analysis,a total of 117 GO items were obtained,and through KEGG signaling pathway enrichment analysis,a total of 92 signaling pathways were obtained.In the network of the main active ingredient-core targe-top 10 signaling pathway,the average number of adjacent nodes was 5.78,and the network centrality was 0.18.The molecular docking energies of the main active ingredients and the core targetswere all less than-7 kcal/mol.The results indicated that the Guiqi Yimu decoction had a good material basis and mechanism of action with multiple effective active ingredients,targets,and pathways in preventing and treating the deficiency of qi and blood in cattle.
国家科技期刊平台
NSTL
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