Effects of γ-aminobutyric acid on growth performance,immune function,and serum biochemical indexes of broilers
The experiment aims to explore the impact of varying proportions of γ-aminobutyric acid(GABA)on the growth performance,immune function,and serum biochemical indexes of broilers.The trial employed a randomized block design,a total of 1 200 one-day-old broilers were divided into four groups with six replicates per group and 50 broilers per replicate.The broilers were fed diets supplemented with 0,10,20 and 40 mg/kg GABA,respectively.The trial lasted for 21 days.The results showed that compared with Group Ⅰ,Group Ⅳ showed an extreme reduction in the feed-to-gain ratio(F/G)(P＜0.01),and there was a significant increase in average daily feed intake(ADFI)and average daily weight gain(ADG)(P＜0.05).The thymus index,bursa index,and the serum levels of immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM),and interferon-γ(IFN-γ)in Group Ⅳ were all significantly elevated(P＜0.05).The serum leptin(Lep)levels in all experimental groups were significantly decreased(P＜0.05).The levels of serum growth hormone(GH),insulin-like growth factor 1(IGF-1),albumin(ALB),and high-density lipoprotein(HDL)in Group Ⅲ and Group Ⅳ were significantly increased,while the levels of total cholesterol(TC)and triglycerides(TG)were significantly reduced(P＜0.05),and the urea nitrogen(BUN)content showed an extreme decrease(P＜0.01).The total protein(TP)and globulin(GLB)content in Group Ⅳ,as well as the levels of cholecystokinin(CCK)and the activity of alanine aminotransferase(ALT),were significantly reduced(P＜0.05).The study suggests that the addition of 40 mg/kg GABA in the feed can enhance broilers'appetite,promote protein deposition in the body,regulate growth and development,and strengthen the immune system.
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