Study on immune enhancement of Cangpu Wumei powder
The experiment was designed to investigate the modulating effect of Cangpu Wumei powder on the immune function of the organism.Cyclophosphamide was used to induce immunosuppression in mice,and different doses of Cangpu Wumei powder were administered to both immunosuppressed and normal mice via gavage.A total of 128 Kunming mice,half male and half female,were randomly divided into eight groups,with 16 mice in each group:The blank control group,the cyclophosphamide model group,the low-dose Cangpu Wumei powder group(0.8 g/kg BW),the medium-dose Cangpu Wumei powder group(1.6 g/kg BW),the high-dose Cangpu Wumei powder group(3.2 g/kg BW),the cyclophosphamide+low-dose Cangpu Wumei powder group,the cyclophosphamide+medium-dose Cangpu Wumei powder group,and the cyclophosphamide+high-dose Cangpu Wumei powder group.The experimental period lasted for seven days.The results showed that the administration of each dose of Cangpu Wumei powder for seven consecutive days could significantly increase the levels of interleukin-2(IL-2),interleukin-6(IL-6),immunoglobulin G(IgG),and interleukin-1β(IL-1β)in the serum of immunosuppressed mice,increase the body weight,spleen index,and thymus index of mice,and repair the atrophy of splenic follicles,unclear thymic structure,and necrosis of lymphocytes induced by cyclophosphamide,with the medium dose showing the best effect.The experiment shows that Cangpu Wumei powder can antagonise the immunosuppression induced by cyclophosphamide,repair the damage of spleen and thymus,and has an immune-enhancing effect.Based on the results of cytokines and histopathologic findings,the best dosage of Cangpu Wumei powder to enhance the immunological function in mice is 1.6 g/kg BW.
万方数据
维普
