Effects of flaxseed lignans on mammary gland development and lactation performance in primiparous rats
The experiment aimed to investigate the effects of flaxseed lignans(SDG)on mammary gland development,lactation performance,and lactation-related hormone levels in primiparous rats.A total of 80 primiparous rats were randomly divided into four groups(20 rats per group).The control group was fed a normal diet,while the test groups Ⅰ,Ⅱ,and Ⅲ were fed a normal diet plus orally administered 125 mg/(L·kg)SDG,5 mg/(L·kg)Br,and 125 mg/(L·kg)SDG+5 mg/(L·kg)Br,respectively.SDG was administered throughout pregnancy,and Br was given from the 14th day of gestation until delivery.Medication was stopped on the day of delivery,and eight pups from each litter were retained for milk production measurement.The experimental period lasted for 15 days.The results showed that the milk production on days 13 and 15 of groups Ⅰ and m was significantly higher than that of group Ⅱ(P＜0.01 or P＜0.05).The mammary gland weight,mammary DNA and RNA content,and the RNA/DNA ratio in test group Ⅰ were significantly higher than those in the control group(P＜0.05),and extremely higher than those in test group Ⅱ(P＜0.01).The acini diameter in the mammary g1ands of rats in test groups Ⅰ and Ⅲ was significantly higher than that in the control group and test group Ⅱ(P＜0.05),and the duct diameter was extremely higher than that in the control group and test group Ⅱ(P＜0.01).The levels of reproductive axis hormones in group Ⅰ were significantly higher than those in the other groups,with estradiol(E2)and prolactin(PRL)were significantly higher than those in test group Ⅱ(P＜0.05),and progesterone(P),follicle-stimulating hormone(FSH),and growth hormone(GH)were extremely higher than those in test group Ⅱ(P＜0.01).The study indicates that the administration of SDG can improve rat mammary function,promote the development of mammary acini and ducts,increase milk production,and elevate lactation-related hormone levels.The effects of different treatment groups on the mammary glands of primiparous rats were ranked as follows:Test group Ⅰ＞test group Ⅲ＞test control group＞test group Ⅱ.
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维普
