Role of diacylglycerol acyltransferase 1 in fat metabolism and ketosis in dairy cows
Ketosis is a highly prevalent nutritional and metabolic disease in dairy cows during the periparturient period,and intense lipolysis is one of the most important factors contributing to ketosis in dairy cows,which is the enzymatic catabolism of triglyceride(TG)in adipose tissue.Diacylglycerol acyltransferase 1(DGAT1),which consists of nine transmembrane α-helices(TM1 to TM9)and three loops(EL1,IL1,and IL2),catalyzes the acylation of diacylglycerol(DG),a key reaction during TG synthesis.DGAT1 can participate in fat uptake and energy metabolism in lipid metabolism,and regulate the transport flux of lipoproteins as well as plasma lipid concentration.In addition,DGAT1 improves adipose tissue catabolism in ketosis cows by enhancing and regulating the expression of lipid synthesis genes and suppressing the expression of lipolysis-related genes.In this paper,the structure of DGAT1 and its key role in TG synthesis and lipid metabolism are discussed in depth,with a view to providing theoretical references and bases for the occurrence and prevention of ketosis in dairy cows.
国家科技期刊平台
NSTL
万方数据
