Effects of Atractylodes extract on growth performance,serum biochemical index,and intestinal barrier health in early-weaned piglets
The study aimed to explore the effect of Atractylodes extract on growth performance,serum biochemical index and intestinal barrier health in early-weaned piglets.A total of 60 early-weaned three-way crossbred(Duroc×Landrace×Yorkshire)piglets at 21 days of age were randomly divided into three groups,with five replicates per group and four pigs per replicate.The diets of Groups A(control group),B,and C were supplemented with 0,100,and 200 mg/kg Atractylodes extract(AE),respectively.The experimental period was 49 days.The results showed that compared with Group A,the final body weight(FBW)and average daily gain(ADG)of piglets in Groups B and C were significantly increased(P<0.05),while the feed-to-gain ratio(F/G)and diarrhea index(DI)were significantly decreased(P<0.05).In the serum of piglets in Groups B and C,the activity of glutathione peroxidase(GSH-Px)and the levels of transforming growth factor-β(TGF-β)and interleukin-10(IL-10)were significantly increased(P<0.05),while the activity of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),and the level of tumor necrosis factor-α(TNF-α)were significantly decreased(P<0.05).The activity of superoxide dismutase(SOD)and catalase(CAT)in the serum of piglets in Group C were significantly increased(P<0.05),and the level of interleukin-6(IL-6)was significantly decreased(P<0.05).Compared with Group A,the villus height(VH)of piglets in Groups B and C were significantly increased(P<0.05),the levels of D-lactic acid(D-Lac)in the intestinal tissue and the activity of diamine oxidase(DAO)and myeloperoxidase(MPO)were significantly decreased(P<0.05),and the permeability of fluorescein isothiocyanate-dextran 4 kDa(FD4)in the intestinal mucosa in Group C was significantly decreased(P<0.05),and the transepithelial electrical resistance(TER)in Group C was significantly increased(P<0.05).Compared with Group A,the expression of Claudin,Occludin,and ZO-1 in the intestinal tight junction proteins of piglets in Groups B and C were significantly increased(P<0.05),the number of Escherichia coli in the feces was significantly decreased(P<0.05),and the number of Lactobacilli was significantly increased(P<0.05).The study shows that the addition of AE to the diet can improve the growth performance,serum biochemical indexes,and intestinal barrier health of early-weaned piglets,and 200 mg/kg AE feeding has the best effect.
Atractylodes extractweaned pigletsgrowth performanceserum biochemical indexintestinal barrier health
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