Bioinformatics is a new interdisciplinary subject which can help clarify and understand the biological significance hided in the mass data by using the tools of mathematics,computer science,statistics and biology.The broad development prospects of Bioinformatics bring out the great development in medical research.Therefore,it is necessary to open the Bioinformatics course for those high grade medical students. In this paper,we explored how to improve the teaching quality of Bioinformatics course from three aspects:the introduction of theoretical course,the practice teaching and the case analysis.The Bioinformatics teach-ing should combine with the medical practice,and further provide the help for those medical students engage in the medical research activities in the future.