Diabetic kidney disease(DKD),as the most common microangiopathy of the diabetic renal system,is the main pathogenetic factor of chronic kidney disease and end-stage renal disease.DKD is clinically characterised by glomerular hyperfiltration and proteinuria,blood creatinine,urea nitrogen,and progressively increasing abnormal renal function,and the main pathological changes are dominated by advanced glomerulosclerosis and tubulointerstitial fibrosis.The pathogenesis of DKD is complex.Mitochondria can play a key role in the development of DKD by intervening in the pathogenesis of DKD and participating in the production of end products of advanced glycosylation,reactive oxygen species,endoplasmic reticulum stress,inflammatory factors,and the activation of renin-angiotensin system.Traditional Chinese medicine extracts and traditional Chinese medicine combinations can regulate mitochondrial autophagy,protect and restore mitochondrial function through the intervention of the PTEN-inducible kinase 1(Pink1)/E3 ubiquitin ligase(Parkin)signalling pathway or mitogenic receptor pathway,and play a role in the prevention,treatment and alleviation of DKD.This paper summarises the research progress of traditional Chinese medicine extracts and traditional Chinese medicine combinations interfering with the expression of mitochondrial autophagy-related mediated signaling pathway in the treatment of DKD,in order to provide reference for the application of traditional Chinese medicine in the prevention and treatment of DKD.
Diabetic kidney diseaseMitochondriaAutophagyTraditional Chinese medicine
万方数据
维普
