Wound healing is the premise of body functional rehabilitation after trauma.If the wound is not treated in time,infection will occur.If the inflammatory process is excessive,the healing speed and quality will be affected.ω-3 polyunsaturated fatty acids(ω-3 PUFAs)play an important role in wound healing and tissue repair,which can inhibit the inflammatory response,promote angiogenesis,regulate the nervous system,control blood glucose levels,inhibit microbial growth,and accelerate wound healing.This review introduces the properties of ω-3 PUFAS and explored the healing mechanism of ω-3 PUFAS in promoting burn,traumatic brain injury wound,diabetic burn and diabetic foot ulcers and the routes of administration.