数理医药学杂志2024,Vol.37Issue(5) :392-397.DOI:10.12173/j.issn.1004-4337.202403024

PD-1抑制剂联合化疗治疗转移性鼻咽癌1例

PD-1 inhibitor combined with chemotherapy in the treatment of metastatic nasopharyngeal carcinoma:a case report

程艳双 王娟 金洁莹 吴求吉 钟亚华
数理医药学杂志2024,Vol.37Issue(5) :392-397.DOI:10.12173/j.issn.1004-4337.202403024

PD-1抑制剂联合化疗治疗转移性鼻咽癌1例

PD-1 inhibitor combined with chemotherapy in the treatment of metastatic nasopharyngeal carcinoma:a case report

程艳双 1王娟 1金洁莹 1吴求吉 2钟亚华1
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作者信息

  • 1. 武汉大学中南医院头颈与儿童肿瘤放化疗科(武汉 430071)
  • 2. 武汉大学中南医院妇科肿瘤放化疗科(武汉 430071)
  • 折叠

摘要

本文回顾性分析了一例晚期鼻咽癌(nasopharyngeal carcinoma,NPC)伴多发肝、肺、淋巴结转移患者的诊治过程.患者接受卡瑞利珠单抗免疫治疗联合化疗后显示出良好的疗效,无进展生存期为55个月.即使治疗期间因新冠疫情中断免疫治疗5个月,患者肿瘤仍得到有效控制,无明显复发转移征象.治疗期间无3~4级治疗相关不良反应,患者生活质量良好.对于复发/转移性NPC,免疫治疗联合化疗给患者带来了显著的生存获益.

Abstract

This paper retrospectively analyzed the diagnosis and treatment process of a patient with advanced nasopharyngeal carcinoma(NPC)accompanied by multiple liver,lung,and lymph node metastases.The patient underwent camrelizumab immunotherapy in conjunction with chemotherapy,and demonstrated positive efficacy with a progression-free survival of 55 months.Despite a 5-month interruption in immunotherapy treatment caused by the CO VID-19 epidemic,the patient's tumor remained well controlled with no apparent signs of recurrence or metastasis.Throughout the treatment,there were no grade 3-4 treatment-related side effects,and the patient's quality of life remained good.Immunotherapy combined with chemotherapy can bring significant survival benefits to patients with the recurrent/metastatic NPC.

关键词

鼻咽癌/PD-1抑制剂/免疫治疗/化疗

Key words

Nasopharyngeal carcinoma/PD-1 inhibitor/Immunotherapy/Chemotherapy

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出版年

2024
数理医药学杂志
武汉大学,中国工业与应用数学学会,医药数学专业委员会

数理医药学杂志

影响因子:0.479
ISSN:1004-4337
参考文献量25
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