Progress of pharmacotherapy in the prevention of ischemia-reperfusion injury during hepatectomy
Hepatic portal blockade and central venous pressure control were often used in hepatectomy to reduce bleeding and ensure a clear surgical field so that the operation can be carried out smoothly,but the process of hepatic portal blockade and opening can lead to hepatic ischemia-reperfusion injury(HIRI),gastrointestinal stagnation,and intestinal bacterial translocation.Therefore,perioperative measures to alleviate HIRI caused by hepatic portal blockade and to improve the safety of surgery have become a hot research topic in hepatic resection.Methods such as ischemic preconditioning,subcooling,drug therapy,and anti-apoptotic gene therapy have emerged,among which drug therapy has the characteristics of strong operability,relative safety,and easy access in clinic,and thus it has received extensive attention.This article summarizes the drugs and mechanisms that are representative of the improvements in HIRI,to provide reference for clinical diagnosis and treatment of HIRI.
Hepatic ischemia-reperfusion injuryHepatectomyDrug therapyPrevention and treatment strategies
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