获得性免疫缺陷综合征合并急性早幼粒细胞白血病1例
Acquired immunodeficiency syndrome complicated with acute promyelocytic leukemia:a case report
徐丽华 1吕小艳 1周芙玲1
作者信息
- 1. 武汉大学中南医院血液科(武汉 430071)
- 折叠
摘要
急性早幼粒细胞白血病(acute promyelocytic leukemia,APL)是急性髓系白血病(acute myeloid leukemia,AML)的一种特殊亚型,具有特定的分子发病机制及预后,在获得性免疫缺陷综合征(acquired immunodeficiency syndrome,AIDS)个体中较少见.由于其罕见性和复杂性,AIDS合并APL患者通常需要采用个体化、精准化的治疗策略.本文报道了 1例AIDS合并APL的患者,给予拉米夫定、依非韦伦、替诺福韦抗病毒及三氧化二砷(arsenic trioxide,ATO)10 mg·d-1联合口服全反式维甲酸(all-trans retinoic acid,ATRA)60 mg·d-1的诱导治疗后,骨髓提示完全缓解.
Abstract
Acute promyelocytic leukemia(APL)is a unique subtype of acute myeloid leukemia(AML)with specific molecular pathogenesis and prognosis,which is rare in individuals with acquired immunodeficiency syndrome(AIDS).Due to its rarity and complexity,patients of AIDS complicated with APL usually require individualized and precise treatment strategies.This paper reported a case of AIDS combined with APL.The patient received therapy consisting of lamivudine,efavirenz,tenofovir,and arsenic trioxide(ATO)10 mg·d-1 combined with oral all-trans retinoic acid(ATRA)60 mg·d-1.After the induction therapy,bone marrow reexamination showed complete response.
关键词
获得性免疫缺陷综合征/人类免疫缺陷病毒/急性早幼粒细胞白血病/急性髓系白血病/治疗Key words
Acquired immunodeficiency syndrome/Human immunodeficiency virus/Acute promyelocytic leukemia/Acute myeloid leukemia/Treatment引用本文复制引用
出版年
2024
NETL
NSTL
万方数据