Objective To evaluate the causal relationship between polyunsaturated fatty acids(PUFA)and colorectal cancer(CRC)through a two-sample Mendelian randomization(MR)study.Methods Based on genome-wide association study(GWAS)data,genetic variations related to PUFA were used as instrumental variables,and CRC was extracted from the GWAS dataset as the outcome indicator.The inverse-variance weighted method MR-Egger regression and weighted median method were used as the main analytical method to assess the causal relationship between omega-3 fatty acids,omega-6 fatty acids,the ratio of omega-3 to total fatty acids,the ratio of omega-6 to total fatty acids,and the omega-6 to omega-3 ratio with CRC risk.Results The inverse variance weighting analysis showed that omega-3 fatty acids[OR=1.14,95%CI(1.06,1.23),P=0.014],omega-6 fatty acids[OR=1.10,95%CI(1.03,1.18),P=0.007],and the omega-6 to omega-3 ratio[OR=0.91,95%CI(0.84,0.99),P=0.006]have direct causal relationships with CRC.The ratio of omega-3 to total fatty acids[OR=1.09,95%CI(0.94,1.26),P=0.164]and the ratio of omega-6 to total fatty acids[OR=1.07,95%CI(0.97,1.18),P=0.226]have no causal relationship with CRC.Conclusion The MR analysis results suggest that there are causal relationships between omega-3 fatty acids,omega-6 fatty acids,and the omega-6 to omega-3 ratio with CRC,while there is no causal relationship for the ratio of omega-3 to total fatty acids and the ratio of omega-6 to total fatty acids.
维普
万方数据