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短链脂肪酸对心肌纤维化的影响与治疗研究进展

Research progress on the effect and treatment of short-chain fatty acids on myocardial fibrosis

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近年来,我国心血管疾病的发病率和死亡率不断攀升,心肌纤维化(myocardial fibrosis,MF)作为心脏疾病发生、心功能恶化的重要病理基础,受到越来越多的关注.随着高通量测序等实验方法的发展,肠道菌群及其代谢产物在治疗消化系统、循环系统及免疫系统疾病等方面的作用逐渐显现.本文探讨了肠道菌群代谢产物之一的短链脂肪酸对MF的影响,以为MF的预防及治疗提供新方向.
In recent years,the morbidity and mortality of cardiovascular diseases have been increasing in China,and as an important pathological basis for the occurrence of heart diseases and the deterioration of heart function,myocardial fibrosis(MF)has received more and more attention.With the development of experimental methods such as high-throughput sequencing,the role of intestinal flora and its metabolites in the treatment of digestive system diseases,circulatory system diseases,and immune system diseases have gradually emerged.In this paper,the effect of short-chain fatty acids,one of the metabolites of intestinal flora,on MF,was discussed,to provide a new direction for the prevention and treatment of MF.

Myocardial fibrosisShort-chain fatty acidsImmune inflammationOxidative stress

刘敉霖、赵晟羽、闫纪蓉、潘悦、瞿惠燕

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上海中医药大学附属曙光医院心血管内科(上海 200120)

心肌纤维化 短链脂肪酸 免疫炎症 氧化应激

国家自然科学基金面上项目

81973656

2024

数理医药学杂志
武汉大学,中国工业与应用数学学会,医药数学专业委员会

数理医药学杂志

影响因子:0.479
ISSN:1004-4337
年,卷(期):2024.37(7)