摘要
近年来,我国心血管疾病的发病率和死亡率不断攀升,心肌纤维化(myocardial fibrosis,MF)作为心脏疾病发生、心功能恶化的重要病理基础,受到越来越多的关注.随着高通量测序等实验方法的发展,肠道菌群及其代谢产物在治疗消化系统、循环系统及免疫系统疾病等方面的作用逐渐显现.本文探讨了肠道菌群代谢产物之一的短链脂肪酸对MF的影响,以为MF的预防及治疗提供新方向.
Abstract
In recent years,the morbidity and mortality of cardiovascular diseases have been increasing in China,and as an important pathological basis for the occurrence of heart diseases and the deterioration of heart function,myocardial fibrosis(MF)has received more and more attention.With the development of experimental methods such as high-throughput sequencing,the role of intestinal flora and its metabolites in the treatment of digestive system diseases,circulatory system diseases,and immune system diseases have gradually emerged.In this paper,the effect of short-chain fatty acids,one of the metabolites of intestinal flora,on MF,was discussed,to provide a new direction for the prevention and treatment of MF.
维普
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