目的 对热淋清临床研究进行主题分析,为未来开展更多热淋清相关研究提供借鉴和参考.方法 检索中国知网、万方、中国生物医学文献数据库(CBM)、PubMed、Embase、Web of Science、Cochrane数据库,获取热淋清相关临床研究.采用VOSviewer 1.6.15软件提取关键词、作者、发表机构、发表期刊字段,并生成高频关键词聚类网络图和高频关键词密度图,采用Ucient 6软件分析热淋清联合用药情况,Microsoft Visio软件绘制研究结局指标思维导图.结果 共纳入180篇热淋清临床研究,发表在118种期刊上,以《临床泌尿外科杂志》发文量最高(7篇);涉及175所机构,其中湖州市中医院、衡水市第二人民医院与解放军总医院发文量并列第一;共455位作者参与研究,单人最高发文量为5篇;涉及26种疾病,以泌尿系感染最为集中.纳入研究以临床疗效和不良反应为主要结局指标,其他指标如症状改善时间、美国国立卫生院慢性前列腺炎症状指数(National Institutes of Health-Chronic Prostatitis Symptom Index,NIH-CPSI)评分、结石排净率等也备受关注;胃肠道反应为最常见不良反应;关键词分析显示,在泌尿系感染和前列腺炎研究中,热淋清常与左氧氟沙星联合使用,在尿道炎治疗中常与克拉霉素联用,在体外冲击波碎石术后用于辅助排石引起较多关注.结论 热淋清现有研究多集中于联合抗生素治疗热淋相关疾病,但整体质量偏低,未来应建立更科学的评价标准,注重不良反应和禁忌症的明确性,提升研究方法的多样性和数据利用度.
Thematic analysis of clinical research on Relinqing
Objective To conduct a thematic analysis of the clinical research on Relinqing,and to provide reference for more clinical research of Relinqing in the future.Methods CNKI,Wanfang Data,CBM,PubMed,Embase,Web of Science,Cochrane databases were searched to obtain clinical researches of Relinqing.VOSviewer 1.6.15 software was used to extract keywords,authors,organizations,and journals,and the clustering network diagram of high-frequency keywords and the density map of high-frequency keywords were generated.Ucient 6 software was used to analyze the combination of drugs used together with Relinqing.Microsoft Visio software was used to draw a mind map of research outcomes.Results A toal of 180 studies on Reqingqing were included,and they have been published in 118 journals,with the Journal of Clinical Urology having the highest number of publications(n=7).175 institutions participated in these studies,among which Traditional Chinese Medical Hospital of Huzhou,The Second People's Hospital of Hengshui and The General Hospital of the People's Liberation Army tied for the institutions with most publications.There were 455 authors contributing to the studies,with the highest individual contribution being five articles.The studies covered 26 diseases,with a predominant focus on urinary tract infections(UTIs).Key outcome measures included clinical efficacy and adverse reactions.Other frequently monitored indicators were symptom improvement time,National Institutes of Health-Chronic Prostatitis Symptom Index(NIH-CPSI)scores,stone clearance rate,etc.Gastrointestinal reactions were the most commonly reported adverse effects.Keyword analysis revealed that Relinqing was frequently co-administered with levofloxacin in studies related to UTIs and prostatitis,while clarithromycin is commonly used with Relinqing in urethritis treatment,and Relinqing's role in promoting stone expulsion following extracorporeal shock wave lithotripsy(ESWL)garnered significant attention.Conclusion The majority of Relinqing studies focus on its use in combination with antibiotics for the treatment of Relin-related diseases,however,the overall quality of research is relatively low.Future studies should establish more scientifically rigorous evaluation standards,clarify adverse reactions and contraindications,and optimize the research methods and data utilization.
万方数据
维普
