数理医药学杂志2024，Vol.37Issue(9) ：695-700.DOI:10.12173/j.issn.1004-4337.202404090

从巨噬细胞极化角度浅析中医药治疗骨质疏松症的治疗思路

Analysis of traditional Chinese medicine treatment for osteoporosis from the perspective of macrophage polarization

党泽亮 王兴盛 王芳 徐世红 姜朝阳 姜登宸 秦启顺 彭培
数理医药学杂志2024，Vol.37Issue(9) ：695-700.DOI:10.12173/j.issn.1004-4337.202404090
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从巨噬细胞极化角度浅析中医药治疗骨质疏松症的治疗思路

Analysis of traditional Chinese medicine treatment for osteoporosis from the perspective of macrophage polarization

党泽亮 1王兴盛 2王芳 3徐世红 2姜朝阳 2姜登宸 1秦启顺 1彭培1
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作者信息

  • 1. 甘肃中医药大学研究生院(兰州 730000)
  • 2. 甘肃省中医院创伤中心(兰州 730050)
  • 3. 甘肃省第二人民医院体检科(兰州 730099)
  • 折叠

摘要

骨质疏松症(osteoporosis,OP)是一种全身性骨微观环境代谢疾病.巨噬细胞极化是指巨噬细胞响应某些微环境改变后的一种活化状态,这种状态下形成的M1、M2型巨噬细胞分别从增加骨吸收、破骨细胞形成及成骨细胞形成方面发挥作用,影响骨微环境.中医药治疗OP也是通过调节骨微环境代谢,从而增加骨吸收、破骨细胞形成.本文从巨噬细胞极化角度出发,阐释中医药在抑制M1型巨噬细胞及促进M2型巨噬细胞上发挥作用,进而抑制骨吸收,抑制破骨细胞形成,增加成骨细胞形成,以发挥调节OP骨微环境代谢的治疗作用.

Abstract

Osteoporosis(OP)is a systemic metabolic disease of the bone microenvironment.Macrophage polarization refers to an activated state of macrophages in response to certain microenvironment changes.In this state,M1 and M2 macrophages form and play a role in increasing bone resorption,osteoclast formation,and osteoblast formation,respectively,affecting the bone microenvironment.Traditional Chinese medicine also increases bone resorption and osteoclast formation by regulating bone microenvironment metabolism.This article elucidates the therapeutic effect of traditional Chinese medicine on inhibiting M1 macrophages and promoting M2 macrophages from the perspective of macrophage polarization,thereby inhibiting bone resorption,inhibiting osteoclast formation,and increasing osteoblast formation,in order to regulate the bone microenvironment metabolism of OP.

关键词

骨质疏松症/巨噬细胞极化/中医药/治疗思路

Key words

Osteoporosis/Macrophage polarization/Traditional Chinese medicine/Treatment strategies

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出版年

2024
数理医药学杂志
武汉大学,中国工业与应用数学学会,医药数学专业委员会

数理医药学杂志

影响因子：0.479
ISSN：1004-4337
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