B7-H4,一个新发现的T细胞免疫负调节分子
B7-H4:a new negative regulator of T cell immunity
刘长征 1杨克恭 1陈松森1
作者信息
- 1. 中国医学科学院,中国协和医科大学基础医学研究所医学分子生物学国家重点实验室,北京,100005
- 折叠
摘要
抗原提呈细胞调控T细胞免疫是通过B7家族中的一类共激活分子完成的,B7-H4是B7家族中一个新成员.人B7-H4基因位于1号染色体,由六个外显子和五个内含予组成,其中的第六个外显子可用于选择性剪接,最终得到两个不同的产物.B7-H4是T细胞免疫的强弱化子,抑制T细胞增殖和细胞因子分泌.近来研究发现B7-H4蛋白在多种肿瘤组织中大量表达,使肿瘤细胞逃避机体免疫系统的攻击.以B7-H4分子为肿瘤治疗靶标,为肿瘤免疫治疗提供了一种新方法.
Abstract
T cell activation by antigen-presenting cell (APC) is regulated by the eostimulatory molecules in the B7 family. B7-H4 is a novel member in this family. The genomic DNA of human B7-H4 is mapped at chromosome 1 and comprised of six exons and five introns, of which exon 6 is used for alternative splicing to generate two different transcripts. B7-H4 is a potent attenuator of T cell response and has a profound effect on the inhibition of growth and cytokine secretion. Recent studies have indicated that B7-H4 protein is overexpressed in a variety of human cancers, which may contribute to the escape of cancers from immune attack. Therefore, it will be a promising approach to improve the efficiency of cancer immuno therapy aimed at B7-H4.
关键词
B7-H4/T细胞免疫/肿瘤/免疫治疗Key words
BT-H4/T cell immunity/cancer/immunotberapy引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据