Application of circulating tumor cell-targeting therapy strategies in anti-tumor metastasis
Metastasis is the major challenge in cancer treatment and is responsible for 90％of cancer-related deaths.Circulating tumor cells(CTCs)are the key to the formation of tumor metastasis,which is closely related to the formation process of tumor metastasis.Therefore,the CTCs-targeting therapeutic strategies have become a hot spot in the research of anti-tumor metastasis.Based on this,this paper reviews the mechanism of CTCs involved in tumor metastasis from three stages:the generation of CTCs,the dissemination of CTCs,and the distal colonization of CTCs.In addition,the research progress of controlling tumor metastasis is summarized from the following aspects:regulating tumor metastasis-related gene expression and inhibiting EMT process to prevent tumor cells from shedding to produce CTCs,capturing and eliminating CTCs in the circulation through activation of autoimmune cells and biomimetic cell membranes or specific molecular-modified nanoparticles,inhibiting the adhesion and passage of CTCs to endothelial cells and disrupt the microenvironment of PMN for tumor cell growth.It provides new ideas for the prevention and treatment of tumor metastasis.
万方数据
维普
