Research progress in plasmid-mediated antibiotic resistance generation of carbapenemase
Carbapenems are the most effective means for the treatment of β-lactamase-resistant Gram-negative bacilli infection,and also one of the most effective antibacterial drugs against drug-resistant bacteria at present.However,a severe ordeal of the selection of clinical antibiotics with the emergence of carbapenemase-resistant bacteria.The common clinical carbapenemases mainly include five enzymes:Klebsiella pneumoniae carbapenemases(KPCs),New Delhi metalloenzyme(NDM),Imipenemase(IMP),Verona integron-encoded metallo-β-Lactamases(VIM),and Oxacillinase(OXA).Most of the genes encoding these enzymes are located on plasmids,and plasmids allow these drug resistance genes to spread horizontally or vertically between bacteria.In this paper,the distribution,expression and dissemination of carbapenemase in Gram-negative bacteria through plasmids were reviewed in order to provide a theoretical basis for the scientific prevention and control of carbapenem-resistant bacteria and the rational use of carbapenem antibiotics.
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