The tumor regulation mechanism and clinical research progress of GPX8
Glutathione peroxidases(GPXs)are important members of the antioxidant enzyme system that promote hydrogen peroxide metabolism and protect cell membrane structure and function from oxidative damage.Among them,GPX8 is the newly discovered family member,which is located in the endoplasmic reticulum and is a non-specific antioxidant enzyme.It has been confirmed that GPX8 gene mutations and the effect on DNA methylation are closely related to tumorigenesis.It was found that it was abnormally expressed in a variety of tumor tissues,affecting the immune microenvironment of tumors,and had important regulatory effects in tumor migration and invasion.However,so far,there are few studies on the mechanism of GPX8 in tumors,in order to fully understand the role of GPX8 in tumors,this article reviews the regulatory mechanism of GPX8 in various tumors such as glioblastoma,gastric cancer and invasive breast cancer,as well as its role in the treatment and prognosis assessment of clinical patients.At the same time,the latest research progress of GPX8 in renal clear cell carcinoma,hepatocellular carcinoma and pancreatic cancer in recent years was described.This article not only summarizes the research status of GPX8,but also summarizes the shortcomings of current research,which provides a favorable theoretical basis for further in-depth study of the regulatory mechanism of GPX8 in tumors and the clinical search for new targeted therapeutic approaches.
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维普
