Roles of IGF2BP1 in malignant tumors of digestive system
Insulin-like growth factor-2 mRNA binding proteins(IGF2BPs)are a family of highly conserved RNA binding proteins that regulate the processing and metabolism of RNA and participate in a variety of cellular pathological and physiological processes.As a subtype of IGF2BPs,IGF2BP1 promotes tumor cell proliferation,growth,invasion,and chemoresistance by binding to and enhancing the stability of cancer-related target mRNA,and is associated with a poorer prognosis.In this paper,we review the structure and function of IGF2BP1,as well as its role and related molecular mechanisms in the progression of malignant tumors and tumor chemotherapeutic resistance in the digestive system,in order to provide a theoretical basis for the development of a clinical molecular targeted therapy for IGF2BP1.
insulin-like growth factor-2 mRNA binding protein 1digestive systemtumorchemotherapy resistance
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