首页|非编码RNA在肿瘤治疗相关心脏毒性中的作用及应用前景

非编码RNA在肿瘤治疗相关心脏毒性中的作用及应用前景

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肿瘤治疗相关心脏毒性(tumor treatment-related cardiotoxicity,TTRC)是导致癌症患者预后不良的重要因素,目前尚无有效的防治策略.非编码RNA(ncRNA)广泛存在于真核生物的细胞核和细胞质中,具有调节基因表达的功能,在TTRC的发生发展中发挥了重要作用.本文对近年来ncRNA在TTRC中的研究成果进行了综述,较详细地阐述了相关作用机制,指出ncRNA在治疗和监测TTRC方面具有广阔的应用前景,分析了目前研究的局限性并提出了相关建议,旨在为该领域的深入研究以及加快临床转化提供新指导与新见解.
Role and application prospect of non-coding RNA in tumor treatment-related cardiotoxicity
Tumor treatment-related cardiotoxicity(TTRC)is an important factor leading to poor prognosis of cancer patients,and there are no effective prevention and treatment measures.Non-coding RNA(ncRNA)widely presents in the nucleus and cytoplasm of eukaryotes,has the function of regulating gene expression and play an important role in the occurrence and development of TTRC.In this paper,the recent research achievements of ncRNA in TTRC are reviewed,and the relevant mechanism is described in detail.It is pointed out that ncRNA has a broad application prospect in the treatment and monitoring of TTRC.The limitations of current research are analyzed and relevant suggestions are put forward.This paper aims to provide new guidance and insights for further research in this field and to accelerate clinical transformation.

non-coding RNAtumorcardiac toxicitytherapeutic targetbiomarker

黄愿、鄢文婷、马永霞、万敬强、王刚、李燕玲、李建锋、谢萍

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甘肃中医药大学第一临床医学院,兰州 730000

甘肃省人民医院心内一科,兰州 730000

非编码RNA 肿瘤 心脏毒性 治疗靶点 生物标志物

国家自然科学基金甘肃省国际科技合作项目兰州市人才创新创业项目甘肃中医药大学研究生创新基金

8186004720YF3WA0112018-RC-72LCCX2021007

2023

生命的化学
中国生物化学与分子生物学会

生命的化学

CSTPCD
影响因子:0.404
ISSN:1000-1336
年,卷(期):2023.43(1)
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