The role of CXCL10-CXCR3 axis in acute lung injury
Acute lung injury(ALI)is a clinically common critical illness of lung infection,the core of which is an excessive inflammatory response.Clinical treatment for ALI is to suppress excessive inflammation and promote damage repair.The chemokines CXCL10 and CXCR3 receptors are closely related to ALI,in which CXCL10-CXCR3 acts on the activation and migration of alveolar macrophages,neutrophils,lymphocytes and other immune cells and thus affects the progression of ALI.This paper reviews how CXCL10-CXCR3 affects the progression of ALI through alveolar macrophages,neutrophils,natural killer cells and other cells,and discusses the CXCL10-CXCR3 as a strategy for the treatment of ALI.
万方数据
维普
