肝癌干细胞(liver cancer stem cells,LCSCs)是肝癌细胞中少量存在并具有较强的自我更新、增殖和分化能力的细胞,在肝癌发生、转移、复发、耐药性方面起着根本性的作用.肿瘤细胞的代谢以及生存机制一直是近年来的研究热点.LCSCs相比于非肝癌干细胞具有更强的糖酵解能力和对肿瘤微环境(tumor microenvironment,TME)的适应能力.本文介绍了LCSCs的特点、糖酵解特性以及其在TME中的适应性机制,为后续应用LCSCs实施精准治疗提供新思路.
Abstract
Liver cancer stem cells(LCSCs)are a small number of liver cancer cells with strong self-renewal,proliferation and differentiation ability.They play a fundamental role in the occurrence,metastasis,recurrence and drug resistance of liver cancer,and the metabolism and survival mechanism of tumor cells have become the focus of research in recent years.Compared with non-hepatoma stem cells,LCSCs have stronger glycolytic ability and adaptability to tumor microenvironment(TME).This article introduces the characteristics of LCSCs,glycolytic characteristics and the adaptive mechanism in their TME,in order to provide a new idea for the follow-up precise treatment of LCSCs.
关键词
肝癌干细胞/有氧糖酵解/乳酸/"瓦伯格"效应/肿瘤微环境
Key words
liver cancer stem cells/aerobic glycolysis/lactic acid/Warburg effect/tumor microenvironment
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