As a complex micro-ecological system that affects the pathophysiological process of the body,lung microorganisms regulate the pathogenic mechanisms of various lung diseases.Studies have found that lung microbes not only participate in various biological processes such as metabolism,inflammation,and immune homeostasis,but also affect the occurrence and development of chronic lung allograft dysfunction(CLAD)after lung transplantation.Lung transplantation is the main treatment for end-stage lung disease,and its postoperative complications have always been an urgent problem to be solved.This article mainly introduces the composition of the lung microbiome in healthy and diseased states and focuses on the relationship between the lung microbiome,immunity,and lung transplant homeostasis,to provide a theoretical basis for the clinical regulation of the lung microecological environment.
维普
万方数据