The proportion of the elderly population in the world has increased significantly,and cardiac aging has been considered as an important and independent risk factor leading to the occurrence and development of cardiovascular diseases.Oxidative stress,inflammation and autophagy are the main molecular regulatory mechanisms during cardiac aging.Therefore,it is essential to understand the structural and functional changes,molecular mechanisms,and preventive strategies of cardiac aging.SIRT3(sirtuin 3)belongs to the sirtuins(SIRTs)family of proteins and plays an important role in the aging of other organs and human diseases.This paper reviews the molecular structure of SIRT3,and summarizes the emerging mechanism and treatment strategies of SIRT3 in cardiac aging,providing reference for the better clinical application of SIRT3 in the future.
维普
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