Research progress of endoplasmic reticulum integrated membrane protein SEC62
Endoplasmic reticulum(ER)is an essential site for protein processing in eukaryotic cells so that processed proteins can reside in ER or be transported to Golgi.If proteins in the ER are not properly folded and transported,a large number of proteins can accumulate in the ER,causing ER stress.SEC62,an endoplasmic reticulum transmembrane protein composed of 399 amino acid residues,plays an important role in maintaining protein homeostasis,participates in the post-translational translocation of secreted proteins and membrane-bound proteins in eukaryotic cells,also can bind with SEC61 channel to regulate calcium homeostasis in endoplasmic reticulum,and is significantly activated during ER stress recovery to maintain ER volume and size.This paper systematically expounds the function of SEC62,the regulated signal pathway,and its role and significance in diseases including virus replication and various cancers.Based on these research results,SEC62 may be used as a new target for antiviral therapy and accurate diagnosis and treatment of tumors,providing new ideas for the development of new drugs.
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