肿瘤坏死因子-α诱导蛋白8样分子2(tumor necrosis factor-α-induced protein 8-like 2,TIPE2)是一种新型的先天免疫和细胞免疫的调节因子.TIPE2负向调节Toll样受体和T细胞受体的功能,其在免疫系统的选择性表达可抑制炎症反应并维持免疫稳态.大量研究表明,TIPE2是多种肿瘤生成和肿瘤免疫平衡动态调节的负性调节分子,是自然杀伤(natural killer,NK)细胞成熟和抗肿瘤免疫的潜在检查点.TIPE2在炎症、免疫相关疾病和肿瘤的发生发展过程中起重要作用,具有作为临床生物标志物的潜力.本文总结了TIPE2的结构特点、生物学功能及其在疾病中的异常表达和临床意义,为疾病治疗提供新的策略.
Research progress of TIPE2 in inflammation,immune-related diseases and cancers
Tumor necrosis factor-α-induced protein 8-like 2(TIPE2)is a novel regulator of innate immunity,as well as cellular immunity.It negatively regulates the functions of Toll-like receptor and T cell receptor,and its selective expression in immune system inhibits inflammation and maintains immune homeostasis.Recent studies have revealed that TIPE2 is a negative regulatory molecule of various tumorigenesis and the dynamic regulation of tumor immune balance,and is a potential checkpoint for natural killer cell(NK)maturation and anti-tumor immunity.TIPE2 plays an important role in the development of inflammation,immune-related diseases and tumors,and is a potential clinical biomarker.This review summarizes the structural characteristics,biological functions,abnormal expression and clinical significance of TIPE2,and provides new strategies for diseases treatment.
tumor necrosis factor-α-induced protein 8-like 2tumorinflammationimmune homeostasis
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