Research progress in the study of artemisinin and its derivatives in the treatment of colorectal cancer
栾诗佳 1范翔 1王洁 1黄菊 1马宁 1高旭 1韩冬1
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作者信息
1. 哈尔滨医科大学基础医学院生物化学与分子生物学教研室,哈尔滨 150081
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摘要
结直肠癌被认为是全球最常见的恶性肿瘤之一,其发病率和病死率在所有癌症中分别位居第三位和第二位.青蒿素是我国自行研制出的抗疟药物,目前关于青蒿素抗癌特性的研究数据迅速增加.本文综述了青蒿素及其衍生物(artemisinin and its derivatives,ARTs)作为抗癌药物在治疗结直肠癌的机制研究、临床试验以及与其他方法联合治疗等方面的研究进展,希望为未来针对ARTs治疗结直肠癌提供理论依据.
Abstract
Colorectal cancer is considered one of the most common malignancies worldwide,with the third highest incidence and second highest mortality rates among all cancers.Artemisinin is a self-developed antimalarial drug in China.At present,data on the anticancer effects of artemisinin are accumulating quickly.This review examined how artemisinin and its derivatives(ARTs)worked as anticancer medications to treat colorectal cancer through mechanistic studies,clinical trials,and research advances.It is planned to offer a theory for colorectal cancer treatment using ARTs in the future.
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