Non-canonical functions of metabolic enzymes and metabolic sensing
Metabolism is the fundamental activity in the body,and the metabolic network composed of metabolic enzymes and metabolites provides the basis of biomass and energy for the life.On one hand,metabolic enzymes-catalyzed metabolites,as substrates and/or products in different metabolic pathways,are tightly regulated and display canonical functions to maintain metabolic homeostasis.On the other hand,accumulating evidence from our research team and others have demonstrated that some metabolic enzymes and metabolites acquire moonlighting functions.They can participate into regulation of cell signaling transduction and/or act as signaling molecules to precisely control metabolism,playing a critical role in the physiological and pathological processes of the organism.
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