摘要
泛素化是真核生物最普遍最重要的翻译后修饰之一,控制基因转录表达、细胞生长死亡、分子运输、代谢、发育和免疫反应等大多数生理过程.经典泛素系统的通路和机制越来越明晰,同时非经典的泛素化也逐渐被发现.本文将对经典泛素系统进行简单回顾,并且对非蛋白底物泛素化、非赖氨酸位点泛素化、非经典E3泛素连接酶等最新非经典泛素化进行阐述.
Abstract
Ubiquitination is one of the most common and important post-translational modifications in eukaryotes,controlling most cellular processes,such as gene transcriptional expression,cell growth and death,molecular transport,metabolism,development and immune response.In recent years,the pathways and mechanisms of the classical ubiquitin system have become increasingly clear,while non-classical ubiquitination has also been gradually discovered.Here,we will briefly review the classic ubiquitin system,and describe the latest non-classical ubiquitination,including non-protein substrate ubiquitination,non-lysine site ubiquitination and non-classical E3 ubiquitin ligases.
基金项目
脑科学重大项目科技创新2030项目(2021ZD0203900)
国家自然科学基金重大研究计划集成项目(92253302)
科技部"蛋白质机器与生命过程调控"重点专项(2018YFA0508200)
维普
万方数据