Mechanism of survival and metastasis of circulating tumor cells in peripheral blood
Metastasis is an important stage in the development of malignant tumors and is the leading cause of cancer-related deaths.Circulating tumor cells(CTCs)shed from primary tumor and/or metastatic lesions into the vasculature and CTCs are commonly described as source of recurrence and metastasis in cancer patients.CTCs disseminate within the bloodstream where most of them die due to the shear forces,anoikis or the attack of immune system.In fact,only a small fraction of CTCs are capable of surviving,seeding distant organs,and eventually giving rise to overt metastatic disease.Therefore,it has great significance to study the mechanism on how CTCs survive and metastasize in bloodstream for the diagnosis and treatment of tumor patients.In this review,we introduce the latest findings regarding CTCs survive and metastasize in blood stream and prospect its development in future.
万方数据
维普
