The role of macrophages in podocyte apoptosis in diabetes nephropathy
Macrophages are the main immune cells infiltrating diabetic nephropathy(DN),and their mediated inflammatory response plays an indispensable role in the occurrence and development of DN.Podocyte injury plays a key role in the pathological mechanism of DN,and podocyte apoptosis is the central event in the development of DN.In recent years,studies have pointed out that M1 macrophages are mainly involved in pro-inflammatory responses to mediate podocyte apoptosis,while M2 macrophages are mainly involved in anti-inflammatory responses and play a protective role on podocytes,helping to repair podocyte damage and avoid podocyte apoptosis.In this review,we discussed the new therapeutic ideas of DN from the perspectives of podocyte apoptosis,DN and macrophages,and macrophages regulating podocyte apoptosis.It was found that inhibiting M1 macrophages activation and promoting M2 macrophages transformation could effectively prevent podocyte apoptosis.Targeting macrophages therapy may be a promising approach to attenuate DN.
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