Sarcopenia is a chronic skeletal muscle disorder characterized by loss of muscle mass and muscle strength or decreased physical function.Irisin is a novel myogenic factor secreted mainly by skeletal muscle cells,which plays an important role in improving sugar,lipid and bone metabolism and alleviating insulin resistance.Several studies have shown that irisin can not only participate in the occurrence and development of sarcopenia by affecting risk factors such as diabetes,osteoporosis,metabolic syndrome,etc.,but also affect the occurrence and development of sarcopenia by regulating mitochondrial metabolic activity,promoting skeletal muscle protein synthesis and hypertrophy,inhibiting protein atrophy and antagonizing the negative muscle regulator myosomatostatin.However,the specific mechanism of irisin affecting sarcopenia is not clear.This paper reviews the correlation between irisin and sarcopenia,in order to provide references for studying the pathogenesis,diagnosis and treatment of sarcopenia.
万方数据
维普
