摘要
肌少症是一种以肌肉质量和肌肉力量丧失或身体机能下降为特征的慢性骨骼肌疾病.鸢尾素是一种主要由骨骼肌细胞分泌的新型肌源性因子,在改善糖、脂及骨代谢,减轻胰岛素抵抗中发挥重要作用.鸢尾素不仅可通过影响糖尿病、骨质疏松、代谢综合征等危险因素参与肌少症的发生发展,还可通过调节线粒体代谢活性、促进骨骼肌蛋白合成和肥大、抑制蛋白萎缩及拮抗负性肌调节因子肌生长抑制素等来影响肌少症的发生发展.然而,目前鸢尾素影响肌少症的具体发生机制尚未明确.本文综述了鸢尾素与肌少症的相关性,旨在为研究肌少症的发病机制、诊断及治疗提供参考.
Abstract
Sarcopenia is a chronic skeletal muscle disorder characterized by loss of muscle mass and muscle strength or decreased physical function.Irisin is a novel myogenic factor secreted mainly by skeletal muscle cells,which plays an important role in improving sugar,lipid and bone metabolism and alleviating insulin resistance.Several studies have shown that irisin can not only participate in the occurrence and development of sarcopenia by affecting risk factors such as diabetes,osteoporosis,metabolic syndrome,etc.,but also affect the occurrence and development of sarcopenia by regulating mitochondrial metabolic activity,promoting skeletal muscle protein synthesis and hypertrophy,inhibiting protein atrophy and antagonizing the negative muscle regulator myosomatostatin.However,the specific mechanism of irisin affecting sarcopenia is not clear.This paper reviews the correlation between irisin and sarcopenia,in order to provide references for studying the pathogenesis,diagnosis and treatment of sarcopenia.
基金项目
潍坊市科技发展项目(WFWSJK-2020-025)
维普
万方数据