The role of Hippo-YAP/TAZ and Notch signaling pathway in liver fibrosis
Hepatic fibrosis caused by viral or metabolic chronic liver disease is a major global health challenge.Hippo-YAP/TAZ pathway and Notch signaling pathway play a crucial role in the progression of hepatic fibrosis.The classical core kinase cascade of Hippo pathway inactivates transcription coactivator YAP/TAZ through phosphorylation under the action of a large number of external signals,thus regulating cell growth and proliferation,stem cell regeneration,tumor formation and other processes.Notch signaling pathway is involved in the occurrence and development of liver disease by regulating lipid metabolism,IR,oxidative stress,autophagy,inflammation and fibrosis.In this paper,the effects of Hippo-YAP/TAZ and Notch signaling pathways on hepatic stele cells,macrophages,hepatic lipid metabolism and the interaction between the two pathways in the process of hepatic fibrosis were reviewed in detail.This paper not only summarizes the research status of the two pathways in hepatic fibrosis,but also summarizes and analyzes the existing problems and future directions in the study of interaction,aiming at providing new targets and theoretical basis for the prevention and treatment of hepatic fibrosis.
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