Possible mechanisms of AMPK modulates the hypothalamic kisspeptin system
Kisspeptin,encoded by the Kiss-1 gene in the hypothalamus,is involved in controlling the hypothalamic-pituitary-gonadal(HPG)axis and can receive signals from energy metabolism hormones/factors.As an important energy metabolism factor in the body,AMPK can directly or indirectly act on Kiss-1 neurons,affecting the expression of the Kisspeptin system,and the normal function of reproductive organs.Therefore,the Kisspeptin system can regulate energy imbalance through the AMPK correlation pathway.This paper reviews the mechanism of AMPK acting on Kiss-1 neurons in the hypothalamus and the regulatory effect of AMPK on the Kisspeptin system after an energy imbalance.This review aims to provide a theoretical basis for studying the relationship between the body′s energy reserves,features of the HPG axis,and reproductive function homeostasis.
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