摘要
大黄素是中药大黄的主要活性单体成分,属于游离型蒽醌类物质.现代药理学表明,大黄素具有抗炎症、抗氧化应激、抗菌、抗纤维化、免疫调节、抗肿瘤等多种药理活性.近年来,体内外实验均证实了大黄素对急性肺损伤(acute lung injury,ALI)、肺纤维化和哮喘等肺部炎症性疾病均具有较好的防治作用,包括抑制炎症信号通路和炎症细胞浸润、减轻肺水肿、改善纤维化、缓解肺部或气道炎症等.因此,本文主要从机制的角度出发,深入总结大黄素治疗ALI、肺纤维化和哮喘的相关研究,以期为大黄素治疗肺部炎症性疾病的深入研究提供一定的理论基础.
Abstract
Emodin is the main active monomer component of Chinese medicine rhubarb,which belongs to the free type anthraquinone substance.Modern pharmacology has shown that emodin has various pharmacological activities such as anti-inflammatory,anti-oxidative stress,anti-bacterial,anti-fibrotic,immunomodulatory and anti-tumor.In recent years,both in vitro and in vivo experiments have demonstrated that emodin has a good effect on acute lung injury(ALI),pulmonary fibrosis asthma,other lung inflammatory diseases,including inhibiting inflammatory signaling pathways and inflammatory cell infiltration,reducing pulmonary edema,improving fibrosis,and relieving lung or airway inflammation.Therefore,this paper mainly summarizes the relevant studies of emodin for the treatment of ALI,pulmonary fibrosis and asthma from the perspective of mechanism,in order to provide some theoretical basis for the in-depth study of rhodopsin for the treatment of inflammatory diseases in the lung.
基金项目
甘肃省中医药管理局中医药科研项目(GZKZ-2020-7)
维普
万方数据