Hepatocellular carcinoma(HCC)is the sixth most common malignant tumor in the world.Many studies have shown that microRNAs(miRNAs)in the exosomes can mediate intercellular communication and transmission to participate in regulating angiogenesis,epithelial mesenchymal transformation,immune microenvironment and other pathways,thereby promoting the growth,proliferation,migration and invasion of HCC cells,as well as drug resistance of tumor cells.In addition,exosomal miRNAs show significant tissue specificity and great potential as novel biomarkers,and have become one of the hot items of fluid biopsy for early-stage HCC.This paper aims to review the molecular mechanism of exosomal miRNAs in the occurrence,development and drug resistance of HCC,and reveal its potential molecular regulatory network,and summarize its application value in the early diagnosis of HCC.
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