N6-methyladenine(m6A)is the most common epigenetic modification in eukaryotic RNA,with massive recognition proteins and a complex regulatory network,which can play a role in gene expression regulation and cell fate determination.Increasingly studies have shown that m6A can not only regulate gene expression at the post-transcriptional level but also extensively participate in the regulation of gene transcription.m6A plays direct role in regulating transcription by affecting RNA polymerase Ⅱ promoter-proximal pausing and R-loop formation,it also plays indirect role through influencing chromatin structure and activity.This paper briefly introduces m6A and m6A co-transcriptional writing,and discusses the regulatory role of m6A in gene transcription and its relevant biological functions.
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