Recently,the Otop1 channel has been identified as a new proton channel,which has high permeability and selectivity for H+.The resolved cryo-EM structure shows that the structure of the Otop1 protein forms a homodimer,and each subunit contains 12 transmembrane helices(TM1-TM12).From the structure,it is inferred that there are three possible proton conduction paths in the Otop1 channel.The Otop1 channel is expressed in vestibule,adipose tissue and taste receptor cells,and participates in a lot of physiological and pathological processes.This paper reviews the structure,characteristics,physiological and pathological functions of the Otop1 proton channel,and discusses the three main physiological processes in which Otop1 is currently involved:its role in otoconia development and phenomena that may result when Otop1 gene is absent or mutated;Otop1 as a proton channel participating in the sour taste conduction process and as a signaling factor target in metabolic homeostasis in obesity,aiming to provide a basis for a deeper study of the Otop1 channel.
关键词
Otop1质子通道/结构/耳石/酸味感知/肥胖的代谢稳态
Key words
Otop1 proton channels/structure/otoconia/sour taste perception/metabolic homeostasis of obesity
维普
万方数据