Research progress of exosome miR-145 and miR-21 in non-small cell lung cancer
Non-small cell lung cancer(NSCLC)is one of the malignant tumors with the highest incidence in the world.Most patients are in the middle and advanced stage when diagnosed,and the prognosis is extremely poor.Exosomes are membrane bodies with a diameter of 40～100 nm that are actively secreted by cells,containing rich substances such as proteins,lipids,microRNAs(miRNAs),and mRNAs,which are involved in the exchange of substances and information between cells.Non-small cell lung cancer(NSCLC)-derived exosome miRNAs are involved in regulating the occurrence,development,invasion and metastasis of non-small cell lung cancer tumor cells,playing an important role in the physiological and pathological processes of tumor cells.This paper will systematically describe the biological characteristics and functions of exosomes,as well as the role of exosomes miR-145 and miR-21 in regulating the progression,early diagnosis,therapeutic target screening and prognosis of non-small cell lung cancer,so as to provide reference for the basic research and clinical application of exosome miRNA.
万方数据
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