The regeneration and repair of critical bone defects is one of the hotspots in orthopaedic research.In bone tissue engineering,the expression profile of active molecules inside extracellular vesicles is often changed by regulating the gene expression of mesenchymal stem cells,thereby enhancing the osteogenic activity of extracellular vesicles and promoting the regeneration and repair of bone defects.However,the specific mechanism by which mesenchymal stem cell-derived extracellular vesicles(MSC-EVs)-promoted bone defect repair is still unclear.Therefore,by reviewing the related research of MSC-EVs in bone defect repair in recent years,this paper expounds the mechanism of MSC-EVs promoting bone defect repair through its internal active substances,which providing a theoretical basis for the scientific and rational application of MSC-EVs for clinical repair of bone defects.
关键词
骨缺损/细胞外囊泡/间充质干细胞/外泌体/骨再生
Key words
bone defects/extracellular vesicles/mesenchymal stem cells/exosomes/bone regeneration
维普
万方数据