Ferroptosis is a new and regulated cell death mode composed of abnormal iron metabolism and accumulation of lipid peroxides.Ischemic stroke is the second most common cerebrovascular disease in the world with the highest fatality rate,disability rate and recurrence rate,and its occurrence is accompanied by the death of a large number of neurons.Existing studies have demonstrated that the neuronal pathogenesis of ischemic stroke is similar to ferroptosis.Ischemic stroke damage in intracellular iron levels,increased lipid peroxide and antioxidant capacity decline phenomenon of iron is similar to the iron dependence of apoptosis in the form of death.Therefore,studying the induction mechanism of ferroptosis in ischemic stroke is beneficial to provide new targets for clinical treatment of stroke.This review will discuss the regulatory mechanism of ferroptosis from iron metabolism,lipid metabolism,amino acid metabolism,active oxygen generating system and the relationship between ferroptosis and ischemic stroke,in order to provide an entry point for ischemic stroke by intervening in ferroptosis and provide reference for its clinical treatment.
万方数据
维普
